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Published on: April 16, 2019
The role of the CBM complex in allergic inflammation and disease
Stanley B DeVore1, Gurjit K Khurana Hershey1
1Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Cincinnati, Ohio.
Insights
The CARD-CC protein family, vital for immune signaling in the CBM complex, is implicated in allergic diseases. Understanding their role in conditions like asthma and dermatitis is crucial for new treatments.
Area of Science:
- Immunology
- Molecular Biology
- Cell Signaling
Background:
- The caspase activation and recruitment domain-coiled-coil (CARD-CC) protein family (CARD9, CARD10, CARD11, CARD14) are key components of the CARD-B-cell lymphoma/leukemia 10-mucosa-associated lymphoid tissue lymphoma translocation protein 1 (CBM) complex.
- CBM complex dysfunction, termed "CBM-opathies," is associated with various immune disorders, including fungal infections, psoriasis, immunodeficiency, and lymphoproliferative diseases.
- Emerging evidence suggests CARD-CC proteins also play a significant role in the development and progression of allergic inflammation and allergic diseases.
Purpose of the Study:
- To review the roles of the four CARD-CC paralogs (CARD9, CARD10, CARD11, CARD14) and their associated proteins (B-cell lymphoma/leukemia 10 and mucosa-associated lymphoid tissue lymphoma translocation protein 1).
- To elucidate the individual and collective contributions of these proteins to the pathogenesis and progression of allergic inflammation.
- To examine their involvement in four major allergic diseases: allergic asthma, atopic dermatitis, food allergy, and allergic rhinitis.
Main Methods:
- Literature review of existing research on CARD-CC proteins and the CBM complex.
- Analysis of studies investigating the molecular mechanisms of CARD-CC protein function in immune signaling.
- Synthesis of data linking CARD-CC protein dysregulation to allergic inflammation and specific allergic diseases.
Main Results:
- The CARD-CC protein family is broadly expressed and essential for immunologic signaling via the CBM complex.
- Dysregulation of CBM proteins leads to a spectrum of CBM-opathies, affecting immune responses.
- Growing evidence implicates CARD-CC proteins in the pathogenesis and progression of allergic inflammation and diseases like asthma, atopic dermatitis, food allergy, and allergic rhinitis.
Conclusions:
- The CARD-CC protein family and the CBM complex are critical regulators of immune responses.
- Understanding the specific roles of CARD-CC proteins in allergic inflammation is essential for developing targeted therapies.
- Further research into CBM-opathies may reveal novel therapeutic strategies for allergic diseases.
Abstract:
The caspase activation and recruitment domain-coiled-coil (CARD-CC) family of proteins-CARD9, CARD10, CARD11, and CARD14-is collectively expressed across nearly all tissues of the body and is a crucial mediator of immunologic signaling as part of the CARD-B-cell lymphoma/leukemia 10-mucosa-associated lymphoid tissue lymphoma translocation protein 1 (CBM) complex. Dysfunction or dysregulation of CBM proteins has been linked to numerous clinical manifestations known as "CBM-opathies." The CBM-opathy spectrum encompasses diseases ranging from mucocutaneous fungal infections and psoriasis to combined immunodeficiency and lymphoproliferative diseases; however, there is accumulating evidence that the CARD-CC family members also contribute to the pathogenesis and progression of allergic inflammation and allergic diseases. Here, we review the 4 CARD-CC paralogs, as well as B-cell lymphoma/leukemia 10 and mucosa-associated lymphoid tissue lymphoma translocation protein 1, and their individual and collective roles in the pathogenesis and progression of allergic inflammation and 4 major allergic diseases (allergic asthma, atopic dermatitis, food allergy, and allergic rhinitis).
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