Generalized gingival necrosis in a patient under methimazole use

Hyperthyroidism is a common disease, with a prevalence between 0.2% and 0.5%, characterized by an increase in the synthesis and release of thyroid hormones. Management of this condition requires medical intervention to correct the hormonal imbalance and control its clinical manifestations. Methimazole is a thionamide derivative considered among the first-choice treatment options for hyperthyroidism. However, it may cause serious side effects such as neutropenia or agranulocytosis, which, although rare, can lead to death. The clinical manifestations of this complication range from fever, ulcerations in the oral and pharyngeal mucosa, tonsillitis, and lymphadenopathy to hemorrhagic necrosis and septicemia. This report describes the case of a patient with generalized gingival necrosis that was related to the use of methimazole for the treatment of hyperthyroidism.