Related Experiment Video
Updated: Aug 31, 2025
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
[Feasibility and safety of closing large left atrial appendage using the LAmbre device]
Insights
The LAmbre occluder shows feasibility and safety for large left atrial appendage occlusion. This study found a high success rate with no major perioperative complications and favorable 12-month outcomes.
Area of Science:
- Cardiology
- Medical Devices
- Interventional Cardiology
Background:
- Left atrial appendage occlusion (LAAO) is a key strategy for stroke prevention in atrial fibrillation.
- Occluding large-diameter left atrial appendages (LAA) presents unique challenges.
- The LAmbre occluder is a device designed for LAAO.
Purpose of the Study:
- To evaluate the feasibility and safety of the LAmbre occluder.
- To assess LAmbre device performance in patients with large-diameter LAAO (≥31 mm).
Main Methods:
- Retrospective cohort study including 32 patients with large LAA orifices (≥31 mm).
- LAmbre device implantation performed between June 2018 and March 2020.
- Follow-up at 45 days, 6 months, and 12 months, monitoring for complications and using esophageal echocardiography or CT for shunt and thrombosis assessment.
Main Results:
- Successful LAmbre device implantation in 96.9% of patients (31/32).
- No major perioperative complications were observed.
- During 12-month follow-up, one patient experienced pericardial tamponade (resolved with treatment); no significant peri-device leaks, device-related thrombi, or thromboembolic events occurred.
Conclusions:
- The LAmbre occluder demonstrates feasibility and safety for LAAO in patients with large LAA diameters.
- The device shows promising outcomes with a low complication rate in this cohort.
Abstract:
Objective: To evaluate the feasibility and safety of the LAmbre occluder for large-diameter left atrial appendage occlusion. Methods: This study was a retrospective cohort study. Patients with large orifice of the left atrial appendage (≥31 mm) and occlusion with the LAmbre device in the Arrhythmia Center of Ningbo First Hospital were included from June 2018 to March 2020. Baseline data were collected and major perioperative complications of left atrial appendage occlusion (including death, stroke, instrumental embolism, cardiac tamponade, and major bleeding events) were recorded. Patients were followed up 45 days, 6 months and 12 months after surgery. The shunt and device-related thrombosis were recorded by esophageal cardiac ultrasound or pulmonary vein CT, and the occurrence of postoperative thromboembolism, bleeding events, death and other serious adverse events were recorded. Results: The average age and left atrial appendage ostial dimension of 32 patients (37.5% women) included in this research were (70.4±8.4) years old and (34.4±2.9) mm. The LAmbre device was successfully implanted in 31(96.9%) patients. No major complications occurred during the perioperative period. During the 12-month follow-up, pericardial tamponade occurred in 1(3.2%) patient and was recovered after treatment. There was no occluder edge shunt>5 mm in patients followed up by esophageal echocardiography. No significant peri-device leak, device-related thrombus, thromboembolism or death event has occurred. Conclusion: The LAmbre occluder may be feasible and safe for large-diameter left atrial appendage occlusion.
