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Imaging Biological Samples with Optical Microscopy

Imaging Biological Samples with Optical Microscopy

Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...

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Related Experiment Video

Updated: Aug 31, 2025

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Single-Cell Resolution Three-Dimensional Imaging of Intact Organoids

Published on: June 5, 2020

Multiscale light-sheet organoid imaging framework.

Gustavo de Medeiros¹, Raphael Ortiz^1,2, Petr Strnad^3,4

¹Friedrich Miescher Institute for Biomedical Research (FMI) Maulbeerstrasse 66, 4058, Basel, Switzerland.

Nature Communications

|August 18, 2022

Summary

This summary is machine-generated.

We developed a novel framework for long-term live-imaging of intestinal organoids, creating digital organoids. This tool enables detailed cell tracking and reveals insights into tissue-scale control of cell division fidelity.

Failed At:

2026-06-19T13:39:41.869543+00:00

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