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Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
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The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
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Related Experiment Video

Updated: Aug 31, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
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Advances in Pituitary Surgery.

Yoon Hwan Byun1, Ho Kang1, Yong Hwy Kim1

  • 1Pituitary Center, Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Endocrinology and Metabolism (Seoul, Korea)
|August 19, 2022
PubMed
Summary

Endoscopic pituitary surgery offers advanced techniques for accessing and resecting sellar tumors, improving outcomes. Innovations in skull base reconstruction address cerebrospinal fluid leakage, enabling more complex tumor removals.

Keywords:
Cerebrospinal fluid leakEndoscopyPituitary glandPituitary neoplasms

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Area of Science:

  • Neurosurgery
  • Otolaryngology
  • Endocrinology

Background:

  • Pituitary surgery has seen significant advancements.
  • Endoscopic techniques are increasingly utilized for skull base access.

Purpose of the Study:

  • To review endoscopic skull base approaches for pituitary tumors.
  • To discuss surgical techniques and reconstruction methods.

Main Methods:

  • Review of current endoscopic skull base approaches.
  • Description of surgical techniques for pituitary adenoma resection.
  • Overview of skull base reconstruction methods for CSF leakage.

Main Results:

  • Endoscopic approaches provide versatile access to sellar tumors.
  • Extracapsular dissection and cavernous sinus exploration enhance tumor resection.
  • Advanced reconstruction techniques improve management of cerebrospinal fluid (CSF) leakage.

Conclusions:

  • Endoscopic pituitary surgery enables gross total resection of complex tumors.
  • Progress in reconstruction techniques facilitates management of postoperative CSF fistulas.