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Impact of depressive disorders on clinical outcomes in patients with chronic heart failure

Grzegorz Opielak1, Tomasz Powrózek1, Aneta Skwarek-Dziekanowska2

  • 1Department of Human Physiology, Medical University of Lublin, Lublin, Poland.

Postepy W Kardiologii Interwencyjnej = Advances in Interventional Cardiology
|August 19, 2022
PubMed

Insights

Depression in chronic heart failure patients is linked to poorer cardiac function, lower nutritional status, and worse laboratory markers. Increased depression severity correlates with more severe clinical outcomes in these patients.

Area of Science:

  • Cardiology
  • Psychiatry
  • Nutritional Science

Background:

  • Depression is a common comorbidity in patients with chronic heart failure (CHF).
  • The relationship between depression and specific clinical parameters in CHF patients remains under-investigated.
  • Existing literature lacks comprehensive studies on nutritional, cardiac, and laboratory markers in depressed CHF populations.

Purpose of the Study:

  • To investigate the prevalence of depression among CHF patients.
  • To compare cardiac, nutritional, and laboratory parameters between depressed and non-depressed CHF individuals.
  • To explore the association between depression severity and clinical outcomes in CHF.

Main Methods:

  • A cohort of 94 CHF patients from the Lubelskie Voivodeship was assessed.
  • Depression was diagnosed using standardized criteria.
  • Cardiac (ejection fraction, NYHA class), nutritional (body weight, BMI, albumin, hemoglobin, fat-free mass), and laboratory (C-reactive protein) parameters were compared between groups.

Main Results:

  • Depression was prevalent in 70.2% of CHF patients.
  • Depressed patients exhibited significantly lower ejection fraction (EF%), worse NYHA class, lower body weight, BMI, serum albumin, and hemoglobin levels.
  • Elevated C-reactive protein (CRP) and increased susceptibility to cachexia were observed in depressed individuals, with severity correlating to poorer outcomes.

Conclusions:

  • Depression in CHF patients is significantly associated with adverse cardiac, nutritional, and laboratory findings.
  • Worsening clinical characteristics in CHF patients are directly related to the severity of depression.
  • These findings highlight the importance of addressing depression in CHF management.
Abstract

Keywords:
cachexiachronic heart failuredepressioninflammationnutrition

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