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Adjuvant Application of Shenmai Injection for Sepsis: A Systematic Review and Meta-Analysis
1Department of Critical Care Medicine, Yuebei People's Hospital, Shaoguan 512000, Guangdong, China.
Evidence-Based Complementary and Alternative Medicine : Ecam
|August 19, 2022
Summary
Shenmai injection combined with standard treatment significantly reduces sepsis mortality and improves patient outcomes. This adjuvant therapy is safe and effective, warranting further investigation for sepsis management.
Area of Science:
- Critical Care Medicine
- Pharmacology
- Integrative Medicine
Background:
- Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
- Effective adjuvant therapies are crucial for improving sepsis outcomes and reducing mortality.
- Shenmai injection, a traditional Chinese medicine, has shown potential in managing critical illnesses.
Purpose of the Study:
- To evaluate the efficacy and safety of Shenmai injection as an adjuvant therapy for sepsis.
- To compare outcomes of sepsis patients treated with Shenmai injection plus regular treatment versus regular treatment alone.
Main Methods:
- A systematic review and meta-analysis of randomized controlled studies were conducted.
- Databases searched included PubMed, Cochrane Library, Wan-FANG, VIP, CNKI, and CBM up to June 2022.
- Primary outcomes included 28-day mortality, case fatality rate, APACHE II score, and inflammatory markers (PCT, TNF-α, IL-6, CRP).
Main Results:
- Shenmai injection significantly decreased 28-day mortality (OR: 0.36) and case fatality rate (OR: 0.32).
- Adjuvant therapy significantly reduced APACHE II scores and levels of TNF-α, IL-6, and CRP.
- No significant difference in adverse event rates was observed between groups.
Conclusions:
- Shenmai injection demonstrates significant efficacy and safety as an adjuvant therapy for sepsis.
- The findings support the further investigation and potential clinical application of Shenmai injection in sepsis management.
- Adjuvant Shenmai injection therapy shows promise in improving sepsis patient survival and clinical status.
