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Minimum infective dose of severe acute respiratory syndrome coronavirus 2 based on the current evidence: A systematic

SeyedAhmad SeyedAlinaghi1, Amirali Karimi2, Hengameh Mojdeganlou3

  • 1Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.

SAGE Open Medicine
|August 19, 2022
PubMed
Abstract

Insights

Determining the minimum infectious dose for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for infection control. This study found the minimum infective dose in humans ranges from 1.26 to 7 × 10^6.25 plaque-forming units (PFU).

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Establishing the minimum infectious dose (MID) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is vital for effective risk assessment and infection control in healthcare settings.
  • Current literature presents a significant gap in robust evidence regarding the precise MID for SARS-CoV-2.

Purpose of the Study:

  • To investigate and define the minimum infectious dose of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2.

Main Methods:

  • A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and Cochrane databases up to July 25, 2021.
  • Included studies underwent rigorous title/abstract and full-text screening, with data from 19 selected studies synthesized for analysis.

Main Results:

  • Nineteen studies, including laboratory data from human and animal hosts, met the eligibility criteria.
  • Infection measurement primarily utilized tissue culture infectious dose 50 (TCID50) and plaque-forming units (PFU).
  • The reported range for the minimum infective dose was 1.26–7 × 10^6.25 PFU.

Conclusions:

  • This study provides a range for the minimum infectious dose of SARS-CoV-2 in humans and animal models.
  • Individual variations in MID may exist due to demographic, immunological, and other factors.
Keywords:
Coronavirus disease 2019minimum infective dosesevere acute respiratory syndrome coronavirus 2

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