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Maximum home blood pressure and cardiovascular outcomes in patients with type 2 diabetes: KAMOGAWA-HBP study

Shinnosuke Hata1, Emi Ushigome1, Takashi Yoshimura1

  • 1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science.

Journal of Hypertension
|August 19, 2022
PubMed

Insights

Maximum home blood pressure, especially evening systolic readings, predicts cardiovascular events in type 2 diabetes patients. Higher maximum blood pressure levels indicate increased risk for these serious health events.

Area of Science:

  • Cardiology
  • Endocrinology
  • Hypertension Research

Background:

  • Maximum blood pressure is a potential indicator of organ damage.
  • Previous research linked maximum home blood pressure to diabetic nephropathy.
  • This study investigates prognostic blood pressure values for cardiovascular events in diabetes patients.

Purpose of the Study:

  • To evaluate the prognostic value of maximum home blood pressure measurements for cardiovascular events.
  • To identify specific blood pressure thresholds associated with increased cardiovascular risk in type 2 diabetes.
  • To determine if maximum morning or evening systolic blood pressure is a stronger predictor.

Main Methods:

  • Retrospective cohort study of 1082 patients with type 2 diabetes.
  • Daily morning and evening blood pressure measurements taken in triplicate for 14 days.
  • Cox hazards model used to assess the risk of the first major cardiovascular event.

Main Results:

  • An incidence rate of 15.7/1000 person-years for major cardiovascular events was observed over a 7.0-year follow-up.
  • Maximum morning systolic blood pressure (SBP) showed a hazard ratio of 1.12 (1.01-1.24) and maximum evening SBP 1.19 (1.07-1.31).
  • Cutoff values of 150 mmHg (morning) and 157 mmHg (evening) for maximum SBP were associated with significantly higher risks (HR 1.73 and 2.30, respectively).

Conclusions:

  • Maximum home blood pressure serves as a significant predictor of future cardiovascular events in individuals with type 2 diabetes.
  • Evening maximum systolic blood pressure appears to be a particularly strong predictor.
  • These findings highlight the importance of monitoring maximum home blood pressure for cardiovascular risk assessment in diabetic patients.
Abstract

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