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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

5.5K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.5K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.3K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.3K
Lineage Commitment01:21

Lineage Commitment

3.1K
Commitment is the  process whereby stem cells:
3.1K
Production of Formed Elements01:34

Production of Formed Elements

1.6K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
1.6K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

4.6K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.6K

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Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells.

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Related Experiment Video

Updated: Aug 31, 2025

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

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Shining a light on hematopoietic stem cells.

Anne Schmidt1

  • 1Institut Pasteur, Department of Developmental and Stem Cell Biology, Université de Paris Cité, CNRS UMR3738, F-75015, Paris, France.

Elife
|August 19, 2022
PubMed
Summary

Advanced microscopy techniques provide new insights into where hematopoietic stem and progenitor cells are located and how they interact. This research clarifies the spatial organization and cellular communication within the hematopoietic system.

Keywords:
correlative lightdevelopmental biologydopamine beta-hydroxylaseelectron microscopyhematopoietic stem cellmicroenvironmentregenerative medicineserial section blockface scanning electron microscopystem cell nichestem cellszebrafish

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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Area of Science:

  • Hematology
  • Cell Biology
  • Microscopy

Background:

  • Hematopoietic stem cells (HSCs) and progenitor cells (HPCs) are crucial for blood formation.
  • Understanding their microenvironment and interactions is key to deciphering blood development and disease.

Discussion:

  • Correlative light and electron microscopy (CLEM) offers high-resolution imaging of cellular structures and their spatial context.
  • This approach allows for detailed visualization of cell-cell contacts and the extracellular matrix in the hematopoietic niche.

Key Insights:

  • Novel details regarding the precise localization of HSCs and HPCs within their niche have been uncovered.
  • Specific interactions between these stem and progenitor cells, as well as with stromal cells, have been elucidated.

Outlook:

  • These findings can inform future research into hematopoietic stem cell transplantation and regenerative medicine.
  • Further application of advanced microscopy may reveal dynamic processes in hematopoiesis and related disorders.