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Related Experiment Video

Updated: Aug 31, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Atogepant for migraine.

Kate Bedrin1, Jessica Ailani2

  • 1MedStar Georgetown University Hospital, Washington, D.C., USA.

Drugs of Today (Barcelona, Spain : 1998)
|August 19, 2022
PubMed
Summary
This summary is machine-generated.

Atogepant is an oral medication approved for migraine prevention. It works by blocking the calcitonin gene-related peptide (CGRP) receptor, a key factor in migraine development.

Keywords:
Analgesic drugsAntimigraine drugsAtogepantCalcitonin gene-related peptide (CGRP) receptor antagonistsGepantsMigraine with auraMigraine without aura

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Calcitonin gene-related peptide (CGRP) is a neuropeptide implicated in migraine pathophysiology.
  • CGRP plays a significant role in vasodilation and cerebrovascular regulation.
  • The trigeminal neuronal system is central to CGRP's vasoactive effects in the cerebrovasculature.

Purpose of the Study:

  • To review the role of CGRP in migraine.
  • To discuss the therapeutic potential of targeting CGRP for migraine treatment.

Main Methods:

  • Literature review of studies on CGRP and migraine.
  • Analysis of the mechanism of action of CGRP receptor antagonists.

Main Results:

  • Atogepant, an oral CGRP receptor antagonist, is approved for migraine prevention.
  • CGRP is a potent vasoactive substance involved in migraine.
  • Targeting CGRP offers a therapeutic strategy for both preventive and abortive migraine treatments.

Conclusions:

  • Atogepant represents a significant advancement in oral migraine prevention.
  • Understanding CGRP's role is crucial for developing effective migraine therapies.