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The Inhibitory Effect on Tumor Cells Proliferation Induced by Arsenic Through DNMTs and its Downstream Molecules: A

Jingyi Zhang1, Sheng Li1, Mingxiao Ma1

  • 1Department of Public Health, School of Medicine, Shihezi University, Shihezi 832000, Xinjiang, China.

Current Pharmaceutical Design
|August 19, 2022
PubMed
Abstract

Insights

Arsenic effectively inhibits tumor cell growth by downregulating DNA methyltransferases (DNMTs) and related molecules. This study suggests arsenic as a potential therapeutic agent for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Investigated the regulatory impact of arsenic on DNA methyltransferases (DNMTs) and their downstream targets in tumor cells.
  • Aimed to elucidate the specific mechanisms of arsenic in cancer treatment.
  • Established a theoretical framework for arsenic's anti-tumor effects.

Approach:

  • Conducted a systematic meta-analysis using RevMan 5.3 and Stata 12.0.
  • Analyzed differences between control and arsenic-treated groups using standardized mean difference.
  • Performed subgroup analyses based on arsenic dose, intervention time, and cell type.

Key Points:

  • Arsenic treatment decreased the expression of DNMT1, DNMT3a, DNMT3b, MMP-9, and β-catenin, while increasing RECK and E-cadherin.
  • High-dose arsenic (> 2 μmol/L) and short-term exposure (≤ 48 h) showed significant effects on these molecules.
  • Arsenic's regulation of DNMT3a was dose-dependent (0-5.0 μmol/L), with dose, time, and cell type influencing heterogeneity.

Conclusions:

  • Arsenic inhibits tumor cell proliferation and viability.
  • The anti-tumor mechanism involves the reduction of DNMTs and modulation of downstream molecules.
  • Arsenic demonstrates promise as a potential anti-cancer therapeutic agent.
Keywords:
ArsenicDNA methylationDNMTscell proliferationmeta-analysismolecular mechanismtreatmenttumor cells

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