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Updated: Aug 3, 2026

Transtubular Endoscopic Posterolateral Decompression for L5-S1 Lumbar Lateral Disc Herniation
Published on: October 14, 2022
Intradiscal Therapies for Lumbar Degenerative Disk Disease
Jose A Canseco1, Arun P Kanhere, Gregory D Schroeder
1From Rothman Orthopaedics, Thomas Jefferson University, Philadelphia, PA.
Abstract:
Discogenic low back pain is a common musculoskeletal complaint in patients presenting to orthopaedic surgeons. In addition to surgical options, there are several nonsurgical intradiscal treatments that have gained interest, ranging from biologic, nonbiologic, cell-based, and molecular therapies. However, there is limited evidence for many of these techniques, and some are still in the clinical trial stage. We describe a broad overview of these intradiscal therapies, the mechanism of action, and the evidence behind them.
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