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Published on: September 16, 2011
Drug hypersensitivity syndrome induced by sulfasalazine: A case report
Dong-Hui Chen1, Hai-Rong Zhou1, Yong-Gang Zhang2
1Department of General Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Introduction:
Drug hypersensitivity syndrome (DHS) induced by sulfasalazine is a serious systemic delayed adverse drug reaction, which is associated with significant morbidity and mortality.
Patient Concerns:
A 52-year-old man was hospitalized for developing a rash after 3 weeks of sulfasalazine treatment for ulcerative colitis (UC).
Diagnosis:
The patient was diagnosed with DHS based on his drug history, clinical manifestations, and laboratory test results.
Interventions:
The patient was administered intravenous glucocorticoids. The patient's condition improved after treatment with human immunoglobulin and antihistamines.
Outcomes:
Combination therapy of glucocorticoid and gamma globulin, the whole-body pruritus disappeared, and no new rash appeared. The whole-body rash subsided or turned dark red.
Conclusion:
This article describes the diagnosis and treatment process of a case of sulfasalazine-induced DHS and reviews the relevant literature to improve clinician understanding and avoid misdiagnosis and missed diagnosis.
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