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Updated: Aug 31, 2025

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
Published on: April 1, 2019
Cold exposure can inhibit tumor growth by activating brown adipose tissue (BAT), a specialized fat that generates heat. This finding highlights a potential new avenue for cancer research and treatment strategies.
Area of Science:
- Oncology
- Metabolism
- Thermoregulation
Background:
- Tumor growth is a complex process influenced by various physiological factors.
- Brown adipose tissue (BAT) is known for its thermogenic properties and metabolic activity.
Purpose of the Study:
- To investigate the effect of cold exposure on tumor growth.
- To explore the role of brown adipose tissue (BAT) activation in mediating this effect.
Main Methods:
- Utilizing animal models exposed to controlled cold environments.
- Monitoring tumor size and metabolic parameters in response to cold exposure.
- Assessing the activation state and function of brown adipose tissue (BAT).
Main Results:
- Significant reduction in tumor growth observed in cold-exposed subjects.
- Increased metabolic activity and heat production associated with brown adipose tissue (BAT).
- Correlation established between BAT activation and tumor growth inhibition.
Conclusions:
- Cold exposure effectively suppresses tumor progression.
- Activation of brown adipose tissue (BAT) is a key mechanism underlying the anti-tumor effect of cold.
- Targeting BAT may offer a novel therapeutic strategy for cancer treatment.
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