Serrated Polyposis Syndrome in a Young Adolescent Patient
Victor L Fox1, Inbar S Spofford2, Brian D Crompton3
1From the Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA.
Journal of Pediatric Gastroenterology and Nutrition
|August 19, 2022
Summary
Serrated polyps, often missed in children, can lead to serrated polyposis syndrome. Early recognition and management are crucial for preventing colorectal cancer in pediatric patients.
Area of Science:
- Gastroenterology
- Pediatric Gastroenterology
- Colorectal Cancer Prevention
Background:
- Serrated polyps are neoplastic colonic lesions with subtle morphology, often underreported during colonoscopy.
- While detection is increasing in adults, serrated polyp detection rates in pediatric colonoscopy remain unknown.
- Serrated polyposis syndrome involves multiple colonic serrated polyps, increasing colorectal cancer risk.
Purpose of the Study:
- To report the diagnosis and management of serrated polyposis syndrome in a pediatric patient.
- To highlight the subtle features of serrated polyps that may lead to underreporting in childhood.
Main Methods:
- Case report of a young adolescent diagnosed with serrated polyposis syndrome.
- Review of colonoscopy findings and management strategies.
Main Results:
- Diagnosis and management of serrated polyposis syndrome in a pediatric case.
- Highlighting subtle features of serrated polyps in a pediatric context.
Conclusions:
- Early recognition and endoscopic management of serrated polyps are vital for cancer prevention in children.
- Underreporting of subtle serrated polyps in pediatric colonoscopy requires further attention.
- Management includes polyp clearance and surveillance or colectomy for serrated polyposis syndrome.
Related Concept Videos
Barrett Esophagus-II: Clinical Manifestations and Management
284
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
284
Barrett Esophagus-I: Introduction
169
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
169
Pleiotropy
40.9K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.9K
Esophageal Strictures-II: Clinical Features and Management
151
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
151
Inflammatory Bowel Disease V: Surgical Management
197
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
197


