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Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

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Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
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Heart Failure VI: Adjunct Therapies01:22

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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

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Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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A Small Animal Model of Ex Vivo Normothermic Liver Perfusion
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Hemoperfusion in the intensive care unit.

Zaccaria Ricci1,2, Stefano Romagnoli3,4, Thiago Reis5,6,7

  • 1Pediatric Intensive Care Unit, Meyer Children's University Hospital, Viale Pieraccini 24, 50139, Florence, Italy. zaccaria.ricci@unifi.it.

Intensive Care Medicine
|August 19, 2022
PubMed
Summary
This summary is machine-generated.

Hemoperfusion, a method to clear inflammatory mediators, shows promise for treating sepsis-induced organ failure. Future clinical trials should focus on highly selected patient groups to demonstrate efficacy.

Keywords:
AdsorptionBlood purificationCOVID-19CytokineHemoperfusionLipopolysaccharideSepsis

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Area of Science:

  • Critical care medicine
  • Immunology
  • Biomaterials science

Background:

  • Sepsis-induced multiple organ failure stems from immune dysregulation.
  • Hemoperfusion, using adsorbent materials, aims to clear humoral factors like cytokines.
  • Technological advancements have improved hemoperfusion devices, leading to new clinical applications.

Purpose of the Study:

  • To review current knowledge on hemoperfusion's technical aspects, safety, and clinical outcomes.
  • To focus on recent literature concerning hemoperfusion in critically ill patients.
  • To discuss optimal clinical trial designs for evaluating hemoperfusion efficacy.

Main Methods:

  • This narrative review synthesizes existing literature on hemoperfusion.
  • It examines technical concepts, safety profiles, and clinical results.
  • It analyzes recent randomized controlled trials and future research directions.

Main Results:

  • Hemoperfusion has been studied for decades with variable results.
  • Newer biocompatible materials enhance hemoperfusion efficiency and broaden indications.
  • Recent trials explore hemoperfusion for critically ill patients, with ongoing investigations.

Conclusions:

  • Hemoperfusion is a developing therapeutic option for critical care.
  • Optimizing clinical trial design, including patient selection and outcome measures, is crucial for demonstrating efficacy.
  • Further research is needed to establish definitive clinical benefits and refine treatment protocols.