Heterosynthons, Solid Form Design and Enhanced Drug Bioavailability.

Area of Science:

• Medicinal Chemistry
• Drug Discovery
• Supramolecular Chemistry

Background:

• Molecular pharmacophores are established markers of drug action in medicinal molecules.
• Current drug design strategies can be complex and costly.
• There is a need for efficient and economical routes to novel drugs with high bioavailability.

Purpose of the Study:

• To propose the heterosynthon as a key element in designing high bioavailability drugs.
• To establish an analogy between molecular pharmacophores and heterosynthons in drug discovery.
• To explore the potential of heterosynthons for more efficient and economical drug development.

Main Methods:

• Conceptual framework development.
• Literature review on pharmacophores and supramolecular synthons.
• Comparative analysis of molecular pharmacophore and heterosynthon roles.

Main Results:

• Heterosynthons can serve as supramolecular synthons analogous to molecular pharmacophores.
• This analogy suggests a novel strategy for drug design.
• Heterosynthons offer a potential route to improved drug bioavailability.

Conclusions:

• The heterosynthon concept provides a promising new paradigm for medicinal chemistry.
• Utilizing heterosynthons may lead to more efficient and cost-effective discovery of novel drugs.
• This approach has the potential to significantly impact the development of high bioavailability therapeutics.