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Related Experiment Video

Updated: Aug 31, 2025

Localization of the Locus Coeruleus in the Mouse Brain

Localization of the Locus Coeruleus in the Mouse Brain

Published on: March 7, 2019

Natural locus coeruleus dynamics during feeding.

Natale R Sciolino¹, Madeline Hsiang¹, Christopher M Mazzone¹

¹Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.

Science Advances

|August 19, 2022

Summary

Noradrenergic neurons in the locus coeruleus (LC-NE) suppress feeding. Their activity decreases with satiety, indicating a role in regulating homeostatic food intake and integrating internal states with external cues.

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Last Updated: Aug 31, 2025

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Published on: March 7, 2019

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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

Area of Science:

Neuroscience
Behavioral Biology
Physiology

Background:

Noradrenergic neurons of the locus coeruleus (LC-NE) are known to be involved in fear-induced feeding suppression.
The role of endogenous LC-NE activity in natural, homeostatic feeding behaviors remains largely unexplored.
Understanding LC-NE's influence on feeding is crucial for comprehending appetite regulation and satiety.

Purpose of the Study:

To investigate the role of endogenous LC-NE activity during homeostatic feeding in mice.
To determine how satiety state modulates LC-NE neural responses to food.
To examine the effects of LC-NE activation on feeding behavior and anxiety.

Main Methods:

Monitoring LC-NE neural activity in mice during food consumption.
Assessing the impact of varying satiety levels on LC-NE responses.
Utilizing optogenetic techniques to activate LC-NE pathways and observe behavioral outcomes.

Main Results:

LC-NE activity was suppressed during food consumption, with reduced responses observed as mice became more satiated.
Satiety attenuated visual-evoked LC-NE activity, suggesting modulation across different behavioral states.
Activation of LC-NE, including the LC to lateral hypothalamus pathway, suppressed feeding and increased anxiety-like behaviors.

Conclusions:

LC-NE neurons play a significant role in modulating homeostatic feeding, with activity inversely related to satiety.
LC-NE integrates internal drives, such as satiety, with external cues to regulate feeding behavior.
These findings highlight LC-NE as a key neural circuit involved in appetite control and stress-related behaviors.