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Dissolution Behavior of Weakly Basic Pharmaceuticals from Amorphous Dispersions Stabilized by a

Derek S Frank1, Prateek Prasad1, Luca Iuzzolino2

  • 1Particle Engineering Lab, Process Research & Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Molecular Pharmaceutics
|August 19, 2022
PubMed
Summary

Amorphous solid dispersions (ASDs) using Eudragit EPO show promise for weakly basic drugs, but their performance depends on gastric pH. Careful formulation is needed to manage drug release and prevent precipitation.

Keywords:
Eudragit EamorphouscPADco-precipitated amorphous dispersionco-precipitationco-processed APIdissolutionlumefantrinepHposaconazoleweakly basic

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