Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

3.4K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
3.4K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

3.6K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
3.6K
T Cell Types and Functions01:24

T Cell Types and Functions

1.3K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.3K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

70.2K
Overview
70.2K
Immunological Memory01:23

Immunological Memory

3.7K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
3.7K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

1.2K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial mGPDH Modulates Fibroblast Function in Diabetic Wound Healing via the SIRT1-c-Myc-TGF-β1 Axis.

Diabetes·2025
Same author

Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice.

European journal of immunology·2025
Same author

Long-chain unsaturated fatty acids released during immune responses stimulate host-microbe trans-kingdom communication.

Cell host & microbe·2025
Same author

GmIRT1.1 from soybean (Glycine max L.) is involved in transporting Fe, Mn and Cd.

Plant physiology and biochemistry : PPB·2024
Same author

Enhancing diabetic wound healing with a pH/glucose dual-responsive hydrogel for ROS clearance and antibacterial activity.

International journal of biological macromolecules·2024
Same author

Local antigen encounter promotes generation of tissue-resident memory T cells in the large intestine.

Mucosal immunology·2024

Related Experiment Video

Updated: Aug 31, 2025

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

24.3K

Intestinal CD8+ tissue-resident memory T cells: From generation to function.

Liqing Cheng1,2, Simone Becattini1,2

  • 1Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

European Journal of Immunology
|August 19, 2022
PubMed
Summary

Tissue-resident memory T cells (Trm) are crucial for immunity. This review explores how intestinal Trm are generated, maintained, and their protective roles against infections and tumors.

Keywords:
anatomical nichesintestinal Trmintestinal tumormucosal immunologytissue imprint

More Related Videos

Murine Superficial Lymph Node Surgery
04:36

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

42.7K
Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis
06:07

Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis

Published on: June 27, 2020

6.8K

Related Experiment Videos

Last Updated: Aug 31, 2025

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

24.3K
Murine Superficial Lymph Node Surgery
04:36

Murine Superficial Lymph Node Surgery

Published on: May 21, 2012

42.7K
Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis
06:07

Isolation of Mouse Kidney-Resident CD8+ T cells for Flow Cytometry Analysis

Published on: June 27, 2020

6.8K

Area of Science:

  • Immunology
  • Cellular Biology
  • Gastroenterology

Background:

  • Tissue-resident memory T cells (Trm), especially CD8+ Trm, are vital for defense against pathogens and tumors.
  • While Trm share core functions, unique tissue-specific molecular cues shape their distinct features.
  • The gastrointestinal tract, a common site for infections and cancer, presents unique challenges and opportunities for Trm development.

Purpose of the Study:

  • To review the generation and maintenance mechanisms of Trm within distinct intestinal niches.
  • To analyze the molecular signals and models involved in intestinal Trm development.
  • To discuss the protective functions of intestinal Trm against infections and tumors, integrating findings from animal and human studies.

Main Methods:

  • Literature review of studies on Trm generation, maintenance, and function in intestinal tissues.
  • Analysis of molecular signals and cellular processes governing Trm imprinting in the gut.
  • Integration of data from animal models and human studies on intestinal Trm.

Main Results:

  • Distinct intestinal niches imprint unique functional characteristics onto Trm populations.
  • Specific molecular cues dictate the generation and maintenance of Trm in different gut segments.
  • Evidence supports a protective role for intestinal Trm against infectious agents and tumorigenesis.

Conclusions:

  • Understanding intestinal Trm heterogeneity is key to harnessing them for therapeutic benefit.
  • Targeting Trm generation and maintenance in the gut offers a promising strategy for enhancing local and systemic immunity.
  • Further research integrating animal and human data will refine therapeutic approaches utilizing intestinal Trm.