Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acquired ring chromosomes in hematological malignancies: A systematic evidence review for diagnostic advances, cytogenomic insights, and clinical significance by an International Consortium on Human Ring Chromosomes (ICHRC) working group.

Cancer genetics·2026
Same author

MYOD1 mutation drives cancer stem cell pathways and therapy-resistance in spindle cell/sclerosing rhabdomyosarcoma.

Nature communications·2026
Same author

Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma.

Cancers·2026
Same author

Crop-OCT: a Fully Integrated Imageomics Pipeline to Identify Regional and Focal Retinopathy in Murine Models.

bioRxiv : the preprint server for biology·2026
Same author

Integrative Single-cell and Spatial Transcriptomic Analysis of Osteosarcoma Reveals Conserved and Distinct Ecosystems Across Sites and Species.

bioRxiv : the preprint server for biology·2026
Same author

Targeting glycerophospholipid biosynthesis overcomes chemoresistance driven by SLFN11 loss in Ewing sarcoma.

Cell death & disease·2026

Related Experiment Video

Updated: Aug 31, 2025

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

73.4K

Neuroblastoma: When differentiation goes awry.

Maged Zeineldin1, Anand G Patel2, Michael A Dyer3

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Neuron
|August 19, 2022
PubMed
Summary

Neuroblastoma, a childhood cancer, arises from arrested neural crest progenitor cells. Understanding this developmental arrest offers new strategies for neuroblastoma treatment.

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.1K
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

16.4K

Related Experiment Videos

Last Updated: Aug 31, 2025

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

73.4K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.1K
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

16.4K

Area of Science:

  • Pediatric Oncology
  • Developmental Biology
  • Cancer Genetics

Background:

  • Neuroblastoma is a significant cause of childhood cancer mortality.
  • Evidence suggests a link between differentiation arrest in neural crest-derived sympathoadrenal cells and neuroblastoma.
  • This developmental arrest model explains key disease characteristics like heterogeneity and regression.

Purpose of the Study:

  • To review the evidence supporting the hypothesis that arrested neural crest progenitor cells cause neuroblastoma.
  • To explore the clinical implications of this concept for disease management.

Main Methods:

  • Literature review and synthesis of existing data.
  • Analysis of developmental biology and cancer genetics research related to neuroblastoma.

Main Results:

  • Accumulated data strongly support the differentiation arrest model for neuroblastoma pathogenesis.
  • This model provides a unified explanation for diverse neuroblastoma features.

Conclusions:

  • Arrested neural crest-derived progenitor cells are a likely origin of neuroblastoma.
  • Targeting this developmental mechanism presents a promising avenue for novel therapeutic strategies.