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Tissue Heavy Metals in Liver Diseases
Sami Akbulut1, Burak Isik1, Muhammed Mehdi Uremis2
1Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya, Turkey.
Transplantation Proceedings
|August 19, 2022
Summary
Chronic liver disease (CLD) patients show higher liver superoxide levels and copper, while healthy donors have more cadmium, selenium, and zinc. Oxidative stress is increased in CLD patients.
Area of Science:
- Hepatology
- Biochemistry
- Toxicology
Background:
- Chronic liver disease (CLD) is associated with altered biochemical profiles.
- Investigating heavy metal and oxidative stress markers in CLD is crucial for understanding disease pathogenesis.
Purpose of the Study:
- To compare heavy metal, oxidant, and antioxidant levels in liver tissue between CLD patients and healthy living liver donors (LLDs).
Main Methods:
- Liver specimens were collected from 59 CLD patients and 59 LLDs.
- Biochemical analyses assessed heavy metal and oxidant-antioxidant biomarker levels.
- Comparative analysis was performed between CLD patients and LLDs.
Main Results:
- CLD patients had higher levels of superoxide dismutase, glutathione peroxidase, total oxidant status, oxidative stress index, and copper.
- Healthy LLDs exhibited significantly higher levels of cadmium, selenium, and zinc.
- Total antioxidant status, manganese, arsenic, and lead levels were similar between groups.
Conclusions:
- Increased superoxide accumulation and copper levels are observed in the liver of CLD patients.
- A higher Cu/Zn ratio was noted in CLD patients.
- Distinct heavy metal profiles exist between CLD patients and healthy liver donors.
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