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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

652
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
652
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Related Experiment Video

Updated: Aug 31, 2025

Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
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Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease

Published on: December 26, 2016

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When the infectious environment meets the AD brain.

Tal Ganz1,2, Nina Fainstein1,2, Tamir Ben-Hur3,4

  • 1Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Molecular Neurodegeneration
|August 19, 2022
PubMed
Summary
This summary is machine-generated.

Systemic infections may accelerate Alzheimer's disease (AD) by introducing bacterial amyloids. This creates a cycle where AD pathology enhances susceptibility to infectious agents, driving neurodegeneration.

Keywords:
Alzheimer’s diseaseAmyloid-βInfectionLipopolysaccharidesMicrogliaNeurodegenerationNeuroinflammationPathogen associated molecular patterns

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Area of Science:

  • Neuroscience
  • Pathology
  • Infectious Diseases

Background:

  • The Amyloid theory posits that Amyloid β (Aβ) deposition initiates Alzheimer's disease (AD) pathogenesis.
  • The infectious theory suggests infectious agents may be etiological causes of AD.
  • This review explores the convergence of these two theories.

Purpose of the Study:

  • To discuss the convergence of the Amyloid and infectious theories of Alzheimer's disease.
  • To present a model for how systemic infections and AD pathology interact.

Main Methods:

  • Review of existing literature on Alzheimer's disease theories.
  • Development of a theoretical model explaining the interplay between infection and AD pathology.

Main Results:

  • Systemic infectious burden can accelerate AD brain pathology through bacterial amyloids and pathogen-associated molecular patterns (PAMPs).
  • Developing AD brain pathology increases susceptibility to neurotoxic PAMPs, driving neurodegeneration via activated microglia.

Conclusions:

  • A model is presented where systemic infections and AD brain pathology interact synergistically.
  • Reciprocal effects create a vicious cycle, fueling Alzheimer's disease pathogenesis.