Sleep optimization to improve glycemic control in adults with type 1 diabetes: study protocol for a randomized...

Area of Science:

• Endocrinology
• Sleep Medicine
• Behavioral Science

Background:

• Type 1 diabetes (T1D) management remains challenging, with most adults not meeting glycemic targets.
• Sleep disturbances are linked to poor glycemic control, diabetes distress, and reduced quality of life in T1D.
• There's a knowledge gap in effective sleep interventions for T1D.

Purpose of the Study:

• To assess the efficacy of a T1D-specific sleep optimization intervention (Sleep-Opt).
• To evaluate Sleep-Opt's impact on sleep variability, duration, glycemic control (A1C, TIR), diabetes distress, self-management, and quality of life.
• To determine if sleep optimization improves outcomes in adults with T1D and sleep issues.

Main Methods:

• A 12-week randomized controlled trial involving 120 adults with T1D and sleep variability or short sleep duration.
• Participants were screened and randomized to Sleep-Opt (wearable tracker, digital content, app, counseling) or a healthy living control group.
• Sleep (actigraphy), glycemic control (A1C, CGM), and patient-reported outcomes were measured at baseline, midpoint, and post-intervention (weeks 6, 12, 24).

Main Results:

• The study is designed to determine the efficacy of the Sleep-Opt intervention.
• Primary outcomes include improvements in sleep variability, sleep duration, and A1C.
• Secondary outcomes encompass glycemic variability, time-in-range (TIR), diabetes distress, self-management, and quality of life.

Conclusions:

• Improving sleep in individuals with T1D is a promising strategy for better diabetes management.
• The Sleep-Opt intervention has the potential to be a valuable component of comprehensive T1D care.
• Further research is needed to fully understand the long-term benefits of sleep optimization in T1D.