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Updated: Aug 31, 2025

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Cytotoxic derivatives of dichloroacetic acid and some metal complexes
Mohammad Hossain1, Shayne Roth1, Jonathan R Dimmock2
1School of Sciences, Indiana University Kokomo, Kokomo, Indiana, USA.
Abstract:
This study outlines a number of studies of dichloroacetic acid (DCA) and some of its derivatives. Although DCA has low cytotoxic potencies, various structural modifications are described which result in potent cytotoxins. In particular, hybrid molecules created from DCA and other bioactive molecules whose modes of action differ from DCA are particularly promising as candidate anticancer agents. Considerable emphasis in this review is placed on various series of compounds that incorporate both platinum and DCA into their structures. In addition, the importance of the formulation of some of the bioactive compounds described herein is revealed.
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