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The integrated comprehension of lncRNA HOXA-AS3 implication on human diseases
Qinfan Yao1,2,3,4, Cuili Wang1,2,3,4, Yucheng Wang1,2,3,4
1Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Qingchun Road 79, Hangzhou, 310003, China.
Summary
Long non-coding RNA HOXA-AS3 (HOXA Cluster Antisense RNA 3) is implicated in human diseases. This review explores its role in cancer and other conditions, highlighting diagnostic and therapeutic potential.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are key regulators in biological processes.
- Dysregulated lncRNA expression is linked to human disease development.
- HOXA Cluster Antisense RNA 3 (HOXA-AS3) is a recently identified lncRNA with emerging roles in pathology.
Purpose of the Study:
- To review the abnormal expression of HOXA-AS3 in various human diseases.
- To summarize the pathobiological functions and regulatory mechanisms of HOXA-AS3.
- To discuss the clinical application potential of HOXA-AS3 in diagnosis, prognosis, and therapy.
Main Methods:
- Literature review of studies on HOXA-AS3 expression and function.
- Analysis of HOXA-AS3's involvement in cellular processes like proliferation, invasion, and migration.
- Examination of HOXA-AS3's correlation with clinicopathologic characteristics in cancer patients.
Main Results:
- HOXA-AS3 is abnormally expressed in multiple diseases, including liver, lung, gastric, and oral cancers, as well as glioma and atherosclerosis.
- HOXA-AS3 acts as a competing endogenous RNA, modulating miRNA expression and biological functions.
- HOXA-AS3 expression correlates with cancer patient characteristics and influences cell proliferation, invasion, and migration.
Conclusions:
- HOXA-AS3 is a significant lncRNA with a critical role in the pathogenesis of diverse human diseases.
- HOXA-AS3 demonstrates considerable potential as a biomarker for disease diagnosis and prognosis.
- Targeting HOXA-AS3 may offer novel therapeutic strategies for various cancers and other conditions.
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