Nucleic acid-based therapeutics for dermal wound healing

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Regenerative Medicine

Background:

• Non-healing wounds present a significant clinical challenge despite advances in understanding wound biology.
• Current therapeutic options for delayed wound healing remain limited.

Purpose of the Study:

• To review the role of nucleic acid (NA)-based therapeutics in wound healing.
• To highlight recent advancements in NA-based nanomedicine and biomaterials for wound treatment.
• To discuss the translational challenges and potential of NA-based therapies, particularly microRNA (miRNA).

Main Methods:

• Literature review of NA-based therapeutic strategies for wound healing.
• Exploration of various NA delivery systems, including dendrimers, nanoparticles, and hydrogels.
• Analysis of recent findings in NA-based nanomedicine and biomaterials.

Main Results:

• Nucleic acids (NAs) like siRNA, miRNA, pDNA, aptamers, and ASOs represent a promising therapeutic avenue for wound healing.
• Diverse delivery systems such as nanoparticles and hydrogels are being investigated for NA administration.
• Significant progress has been made in developing NA-based nanomedicine and biomaterials.

Conclusions:

• NA-based therapeutics hold potential for novel treatments for chronic and non-healing wounds.
• Optimization of NA identification and delivery methods is essential for clinical translation.
• miRNA-based strategies show particular promise but require further development for clinical application.