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Updated: Aug 31, 2025
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
How do we forecast tomorrow's transfusion: Infectious safety?
Roger Y Dodd1, Susan L Stramer1
1American Red Cross Blood Services, Scientific Affairs, Rockville, Maryland, USA.
Future transfusion safety relies on advanced donation testing, pathogen reduction, and rapid responses to emerging infections. Transfusion practices may also evolve with reduced blood use and new alternatives.
Area of Science:
- Transfusion Medicine
- Microbial Safety
- Infectious Disease
Background:
- Transfusion safety has significantly improved due to continuous advancements.
- Current microbial safety levels are very high.
- System failures in transfusion processes are now rare.
Purpose of the Study:
- To identify key factors impacting the future microbial safety of blood transfusions.
- To anticipate challenges and opportunities in maintaining transfusion safety.
- To discuss the evolving landscape of transfusion medicine.
Main Methods:
- Review of current practices and technological advancements in transfusion safety.
- Analysis of potential future risks and challenges.
- Forecasting trends in transfusion medicine and infectious disease emergence.
Main Results:
- Further advances in donation testing and pathogen reduction will enhance safety.
- Unpredictable system failures, though rare, remain a possibility.
- Emerging infections pose a significant and ongoing concern.
- Reduced blood utilization and development of alternatives may alter transfusion practices.
Conclusions:
- Continued vigilance and adaptation are crucial for future transfusion safety.
- Technological and scientific progress will enable faster responses to infectious threats.
- Evolving transfusion practices may necessitate new safety considerations.
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