Association between interleukin-19 gene polymorphisms and maternal puerperal infection

Area of Science:

• Genetics
• Obstetrics
• Infectious Diseases

Background:

• Maternal puerperal infection, a significant cause of maternal mortality, includes endometritis.
• Meconium-stained amniotic fluid has been suggested as a risk factor for postpartum uterine infections.

Purpose of the Study:

• To investigate the potential association between interleukin-19 (IL-19) gene polymorphisms and the incidence of maternal puerperal infection.

Main Methods:

• A case-control study involving 300 pregnant women (150 cases with meconium-stained amniotic fluid, 150 controls with clear amniotic fluid).
• Genomic DNA was extracted, and IL-19 gene polymorphisms at rs2243191 and rs1028181 were analyzed using the ARMS-PCR method.
• Statistical analysis was performed using the chi-square test.

Main Results:

• No significant differences were found in the frequencies of AG, GG, and AA genotypes at rs2243191 and rs1028181 IL-19 gene loci between puerperal infection cases and controls.
• Allele frequencies (G and A) for the studied IL-19 gene polymorphisms also showed no significant difference between the groups.

Conclusions:

• The study concludes that IL-19 gene polymorphisms at rs2243191 and rs1028181 are not significantly associated with maternal puerperal infection in the studied population.