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Switching from risperidone to paliperidone palmitate in schizophrenia: Changes in social functioning and cognitive
Meritxell Tost1, Alex González-Rodríguez2, Raquel Aguayo3
1Department of Mental Health, Parc Taulí Hospital Universitari, I3PT. Sabadell, Spain; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.
Progress in Neuro-Psychopharmacology & Biological Psychiatry
|August 21, 2022
Summary
Switching schizophrenia patients from risperidone to paliperidone palmitate (PP) improved social functioning and cognitive performance. Lower PP doses were linked to greater improvements in social skills.
Area of Science:
- Psychiatry
- Neuroscience
- Pharmacology
Background:
- Paliperidone may offer advantages over risperidone in social and cognitive functioning.
- Investigating the impact of switching antipsychotics is crucial for treatment optimization.
Purpose of the Study:
- To evaluate cognitive improvements after switching from risperidone to paliperidone palmitate (PP).
- To assess changes in social functioning following the medication switch.
Main Methods:
- 27 schizophrenia patients switched from risperidone to PP were assessed at baseline, 3, and 6 months.
- Social functioning measured by Personal and Social Performance Scale (PSP).
- Cognitive function assessed using the MATRICS Consensus Cognitive Battery.
Main Results:
- Significant improvements in PSP scores observed post-switch.
- Cognitive enhancements noted in processing speed, working memory, visual memory, reasoning, and attention.
- Lower PP doses correlated with greater social functioning improvements.
Conclusions:
- Switching from risperidone to PP is associated with enhanced social functioning and cognitive performance in schizophrenia.
- Paliperidone palmitate shows promise for improving outcomes in schizophrenia management.
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