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Endoplasmic reticulum secretory pathway: Potential target against SARS-CoV-2
Maarisha Upadhyay1, Sanjeev Gupta1
1Discipline of Pathology, Cancer Progression and Treatment Research Group, Lambe Institute for Translational Research, School of Medicine, National University of Ireland-Galway, Galway, Ireland.
Virus Research
|August 21, 2022
Summary
This review explores how SARS-CoV-2 exploits the endoplasmic reticulum (ER) secretory pathway for replication. It discusses repurposing FDA-approved ER inhibitors as potential therapeutics against COVID-19.
Area of Science:
- Virology
- Cell Biology
- Drug Discovery
Background:
- COVID-19, caused by SARS-CoV-2, has led to millions of deaths globally.
- Coronaviruses manipulate the endoplasmic reticulum's unfolded protein response for replication.
- SARS-CoV-2 utilizes the ER-Golgi intermediate compartment for virion assembly and transport.
Purpose of the Study:
- To review the role of the ER secretory pathway in SARS-CoV-2 replication.
- To explore therapeutic strategies targeting the ER pathway for COVID-19 treatment.
- To assess the feasibility of repurposing FDA-approved ER inhibitors against SARS-CoV-2.
Main Methods:
- Literature review of existing research on SARS-CoV-2 and ER function.
- Analysis of the ER secretory pathway's involvement in viral replication and egress.
- Evaluation of drug repurposing strategies for targeting ER pathway inhibitors.
Main Results:
- SARS-CoV-2 extensively remodels the ER during infection.
- The ER secretory pathway is crucial for SARS-CoV-2 assembly and transport.
- Targeting the ER pathway presents a viable strategy for antiviral intervention.
Conclusions:
- The ER secretory pathway is a key target for inhibiting SARS-CoV-2 replication.
- Repurposing off-patent, FDA-approved ER inhibitors offers a promising therapeutic avenue.
- Further investigation into ER pathway inhibitors is warranted for COVID-19 drug development.
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