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Updated: Aug 31, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Klotho in diabetic kidney disease: more than dust in the Wnt
Thimoteus Speer1, Stefan J Schunk2
1Translational Cardio-Renal Medicine, Saarland University, Homburg/Saar, Germany.
Abstract:
Activation of the Wnt/β-catenin pathway represents a hallmark in the development of kidney fibrosis. Herein, Chen et al. report that Klotho-derived peptide 6, a peptide mimicking the function of the protein Klotho, directly binds to endogenous Wnt ligands and, thereby, serves as a small-molecule inhibitor of canonical Wnt/β-catenin signaling. In diabetic kidney disease, Klotho-derived peptide 6 reduces glomerular injury and preserves kidney function, highlighting Klotho-derived peptide 6 as a novel therapeutic agent.
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