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Kidney disease progression and collider bias in GWAS
Atlas Khan1, Krzysztof Kiryluk1
1Division of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
None:
New genome-wide meta-analysis for longitudinal kidney function decline identified several genetic loci related to kidney disease progression. The study illustrated the complexity of modeling longitudinal traits in genome-wide association studies and highlighted the issue of a collider bias that can be introduced when a kidney disease progression phenotype is adjusted for baseline kidney function. Herein, we briefly outline the key findings of this study, their limitations, and implications for future studies.
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