Related Experiment Video
Updated: Aug 31, 2025
13:51
Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
Published on: November 10, 2017
15.5K
NIR/pH-responsive chitosan hydrogels containing Ti3C2/AuNRs with NIR-triggered photothermal effect.
Chongchong Liu1, Panping Yang1, Jingguo Li2
1School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
Carbohydrate Polymers
|August 21, 2022
Summary
This study presents a novel dual-responsive chitosan hydrogel for drug delivery. The hybrid material exhibits controlled release of doxorubicin (DOX) triggered by near-infrared light and pH changes, offering advanced anticancer treatment potential.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Chitosan (CS) hydrogels are promising for drug delivery.
- Developing remotely responsive hydrogels is crucial for targeted cancer therapy.
- Incorporating nanomaterials can enhance hydrogel functionality.
Purpose of the Study:
- To create a near-infrared (NIR)/pH-dual responsive chitosan-based hybrid hydrogel.
- To embed Ti3C2@gold nanorods (AuNRs) for NIR responsiveness.
- To achieve efficient and remotely controllable drug delivery of doxorubicin (DOX).
Main Methods:
- Preparation of CS/β-GP/Ti3C2@AuNRs hybrid hydrogel.
- Utilizing CS/β-glycerol phosphate disodium salt (β-GP) crosslinking system.
- Embedding NIR-responsive Ti3C2@gold nanorods (AuNRs) nanosheets.
Main Results:
- High drug loading efficiency for DOX (around 88.5%) due to electronegative cavities.
- Distinct pH response observed from chitosan network collapse in acidic conditions.
- Accelerated DOX release triggered by NIR-induced temperature increase from Ti3C2@AuNRs.
Conclusions:
- The developed hybrid hydrogel exhibits multi-responsiveness to NIR, pH, and thermal stimuli.
- It demonstrates a notable NIR-triggered photothermal effect.
- The material offers promising remotely controllable drug delivery properties for anticancer applications.
