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COVID-19 Infection: A Sparked Ignition to a Thrombotic Storm
Yixin Zhang1, Melissa Oye2, Michael Omar3
1Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.
Cureus
|August 22, 2022
Summary
Thrombotic storm (TS) is a rare, life-threatening condition. This case highlights TS triggered by COVID-19 infection and a spindle cell neoplasm, leading to widespread organ ischemia.
Area of Science:
- Cardiology
- Oncology
- Infectious Diseases
Background:
- Thrombotic storm (TS) is a rare but severe condition characterized by amplified thrombotic pathways and widespread organ ischemia.
- Prompt diagnosis and aggressive management with thrombolytic or anticoagulant therapy are crucial for patient outcomes.
Observation:
- A patient presented with a simultaneous ST-elevation myocardial infarction, multiple pulmonary emboli, aortic thrombi, and bilateral limb ischemia.
- The patient had a recent COVID-19 infection, a known risk factor for thrombotic events.
- Further investigations revealed an underlying spindle cell neoplasm.
Findings:
- The combination of COVID-19 infection and spindle cell neoplasm likely precipitated an exaggerated prothrombotic state, leading to thrombotic storm.
- This case illustrates a complex interplay between infection, malignancy, and hypercoagulability.
Implications:
- Highlights the critical need for multidisciplinary expertise in managing complex thrombotic events.
- Emphasizes the potential for severe thrombotic complications following COVID-19 infection, especially in the presence of underlying neoplasms.
- Underscores the importance of comprehensive diagnostic workup to identify contributing factors in thrombotic storm.
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