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Association between serum calcium levels and first stroke: A community-based nested case-control study.

Congcong Ding1,2, Chonglei Bi3, Tengfei Lin4

  • 1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

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|August 22, 2022
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Summary

Both low and high serum calcium levels increase the risk of first stroke in Chinese adults. This U-shaped association highlights the importance of maintaining optimal serum calcium for stroke prevention.

Keywords:
Chinese populationU-shaped curvecalciumfirst strokeischemic stroke

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Area of Science:

  • Biochemistry
  • Epidemiology
  • Neurology

Background:

  • Existing epidemiologic evidence on serum calcium and stroke risk is limited and inconsistent.
  • The role of serum calcium in the incidence of first stroke requires further investigation.

Purpose of the Study:

  • To evaluate the association between serum albumin-corrected calcium levels and the risk of first stroke.
  • To investigate this association in a Chinese community-dwelling population.

Main Methods:

  • A nested case-control study design was employed.
  • 1,255 first-stroke cases and 1,255 matched controls were analyzed.
  • Serum calcium was measured using inductively coupled plasma mass spectrometry.

Main Results:

  • A U-shaped association was observed between serum albumin-corrected calcium and the risk of total and ischemic stroke.
  • Both the lowest and highest tertiles of serum calcium were associated with increased stroke risk compared to the middle tertile.
  • No significant association was found for hemorrhagic stroke.

Conclusions:

  • Serum calcium levels exhibit a U-shaped relationship with first stroke risk in the Chinese population.
  • Both hypocalcemia and hypercalcemia are linked to a higher risk of first stroke.
  • Maintaining normal serum calcium levels may be crucial for stroke prevention.