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Nutritional status at age 1 year in patients born with esophageal atresia: A population-based, prospective cohort

Suzanne Depoortere1, Alexandre Lapillonne2, Rony Sfeir1

  • 1Univ. Lille, CRACMO Reference Center for Rare Esophageal Diseases, CHU Lille, INFINITE U1286, Lille, France.

Frontiers in Pediatrics
|August 22, 2022
PubMed

Insights

Undernutrition and stunting are common in infants with esophageal atresia (EA). Early factors like prematurity and associated abnormalities, not EA type or surgery, predict growth failure, guiding early nutritional support.

Area of Science:

  • Pediatric Surgery
  • Neonatology
  • Nutritional Science

Background:

  • Esophageal atresia (EA) treatment has improved, yet undernutrition and stunting persist in affected infants.
  • Growth failure remains a significant concern for patients with EA, impacting long-term health outcomes.

Purpose of the Study:

  • To evaluate the nutritional status of infants during their first year after birth with EA.
  • To identify key factors associated with growth failure in this patient population.

Main Methods:

  • A population-based study analyzed data from 1,154 infants born with EA in France (2010-2016).
  • Nutritional status was assessed using body mass index and length-for-age Z scores at 1 year.
  • Logistic regression identified factors associated with undernutrition and stunting (P < 0.20).

Main Results:

  • 15.2% of infants were undernourished and 19% were stunted at 1 year; no significant catch-up growth occurred between 6 months and 1 year.
  • Infants born preterm (41%), small for gestational age (17%), or with abnormalities (55%) faced higher risks of growth failure (P < 0.05).
  • EA type and surgical treatment did not correlate with growth failure.

Conclusions:

  • Undernutrition and stunting are prevalent in the first year of life for infants with EA.
  • Early life factors, independent of EA type or surgery, significantly influence growth outcomes.
  • Identifying high-risk infants (preterm, SGA, with abnormalities) can inform targeted nutritional interventions.
Abstract

Keywords:
catch-upgrowthprematuritysmall for gestational agestuntingsyndromicundernutrition

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