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Related Experiment Video

Updated: Aug 31, 2025

Endoscopic Septoplasty with Limited Two-line Resection: Minimally Invasive Surgery for Septal Deviation
06:13

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Is Irradiated Homologous Costal Cartilage Reliable? A Meta-Analysis of Complication Rates in Rhinoplasty.

Nikita Kadakia1, Cyrus Nguyen1, Saba Motakef2

  • 1University of California Riverside School of Medicine, Riverside, CA, USA.

Plastic Surgery (Oakville, Ont.)
|August 22, 2022
PubMed
Summary

Irradiated homologous costal cartilage (IHCC) is a safe and effective graft material for rhinoplasty, with very low complication rates. This systematic review and meta-analysis confirms its potential as a convenient alternative to autologous grafts.

Keywords:
allograftsirradiated homologous costal cartilagerhinoplasty

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Area of Science:

  • Plastic Surgery
  • Regenerative Medicine
  • Biomaterials

Background:

  • Irradiated homologous costal cartilage (IHCC) offers potential as a convenient, cost-effective graft in rhinoplasty.
  • Previous systematic reviews and meta-analyses on IHCC complications are lacking.

Purpose of the Study:

  • To systematically review and meta-analyze complication rates associated with IHCC use in rhinoplasty.
  • To evaluate IHCC as a potential alternative to autologous cartilage grafts.

Main Methods:

  • Systematic review and meta-analysis adhering to PRISMA guidelines.
  • Searches of PubMed, Cochrane, Embase, and Web of Science databases.
  • Inclusion/exclusion criteria screening; random-effects model for pooled complication rates.

Main Results:

  • 11 studies with 1017 patients and 1956 IHCC grafts analyzed; mean follow-up of 47 months.
  • Pooled complication rates: resorption 1.14%, warping 0.5%, infection 1.2%, mobility 1.0%, removal/replacement 0.8%.
  • No reported allergic reactions or systemic diseases; all complications were low.

Conclusions:

  • IHCC demonstrates very low overall complication rates in rhinoplasty.
  • IHCC presents a viable, convenient, and cost-effective alternative to autologous cartilage, avoiding donor-site morbidity.