Related Experiment Video
Updated: Aug 31, 2025
11:36
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
3.1K
Rituximab-induced autoimmune hepatitis: A case study and literature review
Polymnia Galiatsatos1, Sarit Assouline2, Adrian Gologan3
1Division of Gastroenterology, Department of Medicine, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Canadian Liver Journal
|August 22, 2022
Summary
This study reports a rare case of autoimmune-type drug-induced liver injury following rituximab treatment for MALT lymphoma. It highlights a previously undocumented adverse effect of this common immunotherapy.
Area of Science:
- Immunology
- Hepatology
- Oncology
Background:
- Rituximab is a CD20 monoclonal antibody used for B-cell lymphomas and autoimmune conditions.
- Hepatitis B reactivation is a known risk with rituximab, but autoimmune liver injury is not.
- Literature review indicates a gap in understanding rituximab's potential for causing autoimmune liver injury.
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