Mending the broken valentine heart: a case report
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Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model
Published on: March 18, 2019
Sarandeep Marwaha1, Raghav Bhatia1, Michael Papadakis1
1Department of Cardiology, St George's, University of London, St George's University Hospitals NHS Foundation Trust, London SW17 0RE, UK.
Insights
Surgical resection of left ventricular (LV) aneurysm and thrombus improved LV function in a patient with severe impairment post-myocardial infarction (MI). This case highlights LV aneurysmectomy as a beneficial option for complex MI complications.
Area of Science:
- Cardiology
- Cardiac Surgery
- Medical Imaging
Background:
- Mortality from myocardial infarction (MI) has decreased due to primary percutaneous intervention.
- Late complications like left ventricular (LV) dysfunction, aneurysms, and thrombus formation remain challenging.
- Surgical LV wall resection offers variable outcomes for selected complicated cases.
Observation:
- A 66-year-old man presented with dyspnea 2 years post-MI, exhibiting severe LV systolic impairment (23%) and a giant LV aneurysm with a large thrombus.
- The patient's condition had deteriorated from previous assessments.
- The LV aneurysm's appearance was described as resembling a Valentine heart.
Findings:
- The patient underwent successful resection of the LV aneurysm and thrombus.
- Post-surgery, the patient remained asymptomatic.
- Significant improvement in LV function was observed, increasing to 47% at 5 months post-operation.
Implications:
- Imaging and follow-up are crucial after large MI, especially after thrombus resolution.
- LV aneurysmectomy should be considered for patients with large LV aneurysms, severe LV impairment, and thrombus for prognostic and symptomatic benefits.
Background:
Mortality from myocardial infarction (MI) has been decreasing since the introduction of primary percutaneous intervention. Late complications still pose a dilemma, such as deterioration of left ventricle (LV) function, LV aneurysms, and LV thrombus formation. If not adequately managed in a timely manner, this can result in life-threatening consequences. Restoration of LV function by surgical resection of the infarcted LV wall is an option for a few complicated cases, with variable outcomes.
Case Summary:
A 66-year-old man presented with dyspnoea 2 years after his initial MI, which was treated with a drug-eluting stent to his left circumflex artery. His Warfarin had been stopped after 6 months of treatment of a small LV thrombus, which was noted at the time of his initial infarction. His echocardiogram on admission demonstrated severe LV systolic impairment of 23% (which had deteriorated from 40%) with a giant true aneurysm of the basal to mid-lateral wall, which resembled a Valentine heart. The presence of a large, organized thrombus filling the aneurysm complicated the case further. The patient underwent a resection of the LV aneurysm and thrombus. He remained asymptomatic and maintained a significant improvement of his LV function to 47% at his 5 months scan.
Discussion:
The importance of imaging post-large MI and follow-up imaging once thrombus resolution has occurred is crucial. Patients with large LV aneurysm associated with severe refractory LV impairment and LV thrombus should be considered for LV aneurysmectomy for prognostic benefit and symptom relief.
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