Mixed Neuroendocrine - Nonneuroendocrine Neoplasm Arising in Barrett's Esophagus

Barrett's esophagus, which results from chronic gastroesophageal reflux disease, is a known precursor to dysplasia and ultimately esophageal adenocarcinoma. Mixed neuroendocrine - nonneuroendocrine neoplasm (MiNEN) is a rare and heterogenous group of neoplasm with aggressive clinical behavior in general. There have been rare reports of MiNEN arising in Barrett's esophagus, and its pathogenesis remains unclear. Surgical resection with lymph node dissection remains the most effective treatment of MiNEN of the esophagus to date, although the evidence on its optimal treatment is scant.

Lee SL, Ng CY, Gew LT, et al. Mixed Neuroendocrine - Nonneuroendocrine Neoplasm Arising in Barrett's Esophagus. Euroasian J Hepato-Gastroenterol 2022;12(1):57-59.