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Related Experiment Video

Updated: Aug 31, 2025

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice

Published on: July 29, 2022

Murine typhus.

Seamus Lonergan¹, Gowtham Ganesan², Stephen J Titus²

¹Department of Emergency Medicine, Baylor University Medical Center, Dallas, Texas.

Proceedings (Baylor University. Medical Center)

|August 22, 2022

Summary

Murine typhus, a rare rickettsial disease, can present with unusual gastrointestinal symptoms instead of the typical fever, rash, and headache. Early diagnosis is crucial, as pet owners with fleas are susceptible.

Keywords:

Cardiomegaly Rickettsia typhi hepatosplenomegaly murine typhus

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Area of Science:

Infectious Diseases
Bacteriology
Public Health

Background:

Murine typhus is caused by Rickettsia typhi, a gram-negative bacterium.
Classical symptoms include fever, rash, and headache.
It is transmitted by fleas, often associated with rodents and domestic animals.

Observation:

A rare case of murine typhus presented primarily with fever and gastrointestinal distress.
Initial imaging revealed cardiomegaly and hepatosplenomegaly.
The patient's presentation deviated from the classic triad of symptoms.

Findings:

Diagnostic workup confirmed rickettsial disease.
The case highlights atypical clinical manifestations of murine typhus.
Rickettsia typhi infection was identified as the cause.

Implications:

This case broadens the understanding of murine typhus presentations.
It emphasizes the importance of considering rickettsial diseases in patients with unexplained fever and GI symptoms.
Pet owners and individuals with potential flea exposure should be aware of this zoonotic risk.