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Retropharyngeal abscess in the setting of multisystem inflammatory syndrome in children

Darshan B Patel1, Madison L Buras2, Kimberly Walter1

  • 1Department of Pediatrics, Baylor Scott & White McLane Children's Medical Center, Temple, Texas.

Proceedings (Baylor University. Medical Center)
|August 22, 2022
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) can present unusually following SARS-CoV-2 infection. A boy with a resistant retropharyngeal abscess showed MIS-C indicators, linked to Omicron variant COVID-19.

Area of Science:

  • Pediatric infectious diseases
  • Immunology
  • Cardiology

Background:

  • Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition linked to SARS-CoV-2 (COVID-19).
  • Early recognition and diagnosis are crucial for effective management of MIS-C.
  • The spectrum of MIS-C presentations continues to evolve, particularly with new SARS-CoV-2 variants.

Observation:

  • A 13-year-old male presented with a retropharyngeal abscess that did not respond to standard antibiotic treatment.
  • Clinical evaluation revealed laboratory markers indicative of significant systemic inflammation.
  • These markers included elevated levels of interleukin-6, ferritin, and troponin.

Findings:

  • The patient's presentation and laboratory findings were consistent with a diagnosis of MIS-C.
  • The preceding SARS-CoV-2 infection was confirmed to be caused by the Omicron variant.
  • This case highlights a potential atypical manifestation of MIS-C presenting as a refractory retropharyngeal abscess.

Implications:

  • This case expands the understanding of MIS-C's diverse clinical manifestations in pediatric patients.
  • It underscores the importance of considering MIS-C in children with severe, unexplained inflammatory conditions, even with unusual symptoms.
  • Further research may be needed to explore the specific association between SARS-CoV-2 Omicron variant infections and atypical MIS-C presentations.

Keywords:
COVID-19MIS-COmicronphlegmonretropharyngeal abscess

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