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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Pulmonary Embolism I: Introduction01:29

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Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
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Blood and Nerve Supply to the Bones01:29

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
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Related Experiment Video

Updated: Aug 31, 2025

Femoral Bone Marrow Aspiration in Live Mice
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Published on: July 5, 2014

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Fatal bone marrow embolism.

Rasmey Thach1, Alexandra Cina2, Lorenzo Gitto3

  • 1William Beaumont Army Medical Center, Fort Bliss, Texas.

Proceedings (Baylor University. Medical Center)
|August 22, 2022
PubMed
Summary
This summary is machine-generated.

A femoral fracture led to bone marrow embolism, causing multi-organ failure and death. Definitive diagnosis of this rare condition requires postmortem histopathological analysis.

Keywords:
Autopsybone marrow embolismfat embolismfat embolism syndromerespiratory failure

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Area of Science:

  • Pathology
  • Emergency Medicine
  • Trauma Surgery

Background:

  • Bone marrow embolism is a rare but potentially fatal complication.
  • It can arise from various injuries, including fractures.

Observation:

  • A 45-year-old male presented with fever, hypotension, respiratory distress, and altered mental status following a femoral fracture.
  • Autopsy revealed bone marrow particles in pulmonary arteries and fat emboli in the heart and liver.

Findings:

  • Histopathological analysis confirmed bone marrow embolism as the cause of death.
  • The autopsy findings included pulmonary artery obstruction and microvascular fat deposition.

Implications:

  • Clinical diagnosis of bone marrow embolism is challenging due to non-specific symptoms and potential multi-organ involvement.
  • Postmortem histopathological examination is crucial for definitive diagnosis and understanding the pathophysiology.