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Enhanced terahertz sensitivity for glucose detection with a hydrogel platform embedded with Au nanoparticles
Jingjing Zhao1,2, Shaohua Lu1,2, Julio Bastos-Arrieta3,4
1Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, 518060, China.
Biomedical Optics Express
|August 22, 2022
Summary
This study enhances terahertz glucose sensing using a hydrogel with gold nanoparticles. This novel approach improves sensitivity for detecting glucose in physiological solutions.
Area of Science:
- Biomedical Engineering
- Materials Science
- Analytical Chemistry
Background:
- Terahertz spectroscopy is a promising technique for glucose sensing.
- Current methods face challenges in sensitivity and specificity for physiological glucose levels.
Purpose of the Study:
- To develop a hydrogel-based platform for enhanced terahertz glucose sensing.
- To investigate the role of gold nanoparticles in improving sensor sensitivity.
Main Methods:
- Fabrication of a hydrogel platform embedded with gold nanoparticles.
- Terahertz time-domain spectroscopy (THz-TDS) measurements of glucose solutions.
- Application of isotherm models to analyze concentration-dependent absorption coefficients.
Main Results:
- The hydrogel platform with gold nanoparticles significantly enhanced glucose detection sensitivity compared to direct THz-TDS.
- Absorption coefficients were clearly distinguishable across physiological glucose concentrations (0-0.8 mg/mL).
- Isotherm models accurately described the glucose concentration-absorption coefficient relationship (R² = 0.9977).
Conclusions:
- Gold nanoparticles catalyze glucose oxidation, inducing pH changes that enhance terahertz absorption.
- The developed hydrogel platform offers a sensitive and accurate method for terahertz glucose sensing.
- This strategy holds potential for non-invasive glucose monitoring applications.
