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Updated: Aug 31, 2025
08:46
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
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A Decrease in Hb and Hypoproteinemia: Possible Predictors of Complications in Neonates with Late-Onset Sepsis in a
Na Cai1, Wei Liao1, Zhiqiang Chen1
1Department of Pediatrics, The First Hospital Affiliated to Army Medical University, Chongqing, 400038, People's Republic of China.
International Journal of General Medicine
|August 22, 2022
Summary
A decrease in hemoglobin and hypoproteinemia are key predictors of complications in late-onset sepsis (LOS) in newborns. Early identification of these factors can help anticipate adverse outcomes in neonates.
Area of Science:
- Neonatal Medicine
- Pediatric Infectious Diseases
- Clinical Hematology
Background:
- Late-onset sepsis (LOS) is a significant cause of morbidity and mortality in neonates.
- Predicting complications in neonates with LOS is crucial for timely intervention and improved outcomes.
Purpose of the Study:
- To identify predictors of complications in neonates diagnosed with late-onset sepsis (LOS).
Main Methods:
- Retrospective cohort study in a neonatal intensive care unit (June 2016 - February 2020).
- Comparison of demographic, perinatal, hematological, and treatment data between neonates with and without LOS complications.
- Binomial stepwise logistic regression and receiver operating characteristic (ROC) analysis were employed.
Main Results:
- Eighty-seven neonates with LOS were analyzed.
- Significant differences observed in hemoglobin (Hb), Hb decrease, hypoproteinemia, and red blood cell transfusions between complicated and non-complicated groups.
- Moderate to severe anemia at sepsis onset increased complication likelihood.
- A decrease in Hb (OR=0.045) and hypoproteinemia (OR=0.266) were identified as independent predictors of complications.
Conclusions:
- A decrease in hemoglobin and hypoproteinemia are independent predictors of complications in neonates with LOS.
- These factors can aid in the early prediction of complications, facilitating prompt management.
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