Case report: Corticosteroids-induced acute diabetic peripheral neuropathy.

Area of Science:

• Endocrinology
• Neurology
• Pharmacology

Background:

• A 62-year-old man with IgA nephropathy and a history of pancreatic surgery was undergoing treatment.
• He had a history of normal plasma glucose levels prior to steroid administration.

Observation:

• Prednisolone acetate administration led to hyperglycemia (fasting plasma glucose 7.1 mmol/L) with symptoms of polydipsia, polyuria, and weight loss.
• Within three months, the patient developed peripheral neuropathy symptoms including lower extremity numbness, weakness, and muscle cramps.

Findings:

• Electromyography confirmed peripheral nerve impairment in the lower extremities, diagnosing diabetic peripheral neuropathy.
• Discontinuation of steroids and treatment with mecobalamin and acupuncture resulted in partial recovery of strength and sensation over eight months.

Implications:

• This case illustrates a specific adverse drug reaction of corticosteroids, inducing diabetes mellitus and acute-onset diabetic peripheral neuropathy.
• Highlights the importance of vigilant glucose monitoring in patients receiving corticosteroid therapy.
• Suggests potential for recovery from steroid-induced neuropathy with timely intervention.