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Updated: Aug 31, 2025

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
Published on: April 18, 2025
Amyloid PET ordering practices in a memory disorders clinic.
Katherine W Turk1,2,3, Ana Vives-Rodriguez1,2, Kylie A Schiloski1
1Center for Translational Cognitive Neuroscience VA Boston Healthcare System Boston Massachusetts USA.
Approximately one-third of veterans in a memory clinic received amyloid positron emission tomography (PET) scans, with most meeting appropriate use criteria. Many eligible patients did not receive this diagnostic tool for Alzheimer's disease (AD).
Area of Science:
- Neurology
- Radiology
- Geriatrics
Background:
- Amyloid positron emission tomography (PET) scans aid in diagnosing Alzheimer's disease (AD).
- Understanding current ordering patterns within the Veterans Affairs (VA) system is crucial for future healthcare policy.
- Assessing the utilization of advanced neuroimaging in memory disorder clinics provides insights into diagnostic practices.
Purpose of the Study:
- To evaluate the frequency and appropriateness of amyloid PET scan ordering in a VA memory disorders clinic.
- To identify clinical characteristics associated with amyloid PET scan orders.
- To determine the proportion of eligible patients who received amyloid PET scans.
Main Methods:
- Retrospective analysis of 565 veterans' medical records in a VA memory disorders clinic.
- Assessment of clinical features predictive of amyloid PET scan ordering.
- Evaluation of patient adherence to appropriate use criteria for amyloid PET scans.
Main Results:
- 34.9% of veterans received an amyloid PET scan, with 98.0% meeting appropriate use criteria.
- Patients receiving PET scans were younger and more likely to have an initial diagnosis of Alzheimer's disease (AD).
- 64.4% of patients who did not receive a scan met the criteria for its use.
Conclusions:
- The majority of amyloid PET scans ordered in this VA memory clinic adhered to appropriate use criteria.
- A significant number of eligible patients did not receive amyloid PET scans, indicating potential underutilization.
- Findings have implications for memory disorder clinics within and beyond the VA system regarding diagnostic imaging access and utilization.
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