Related Experiment Video

Updated: Aug 31, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.4K

Clinical Features of Neurodevelopmental Outcomes in Children with Preterm Severe Fetal Growth Restriction: A

Takahiro Motoki1, Yoshitsugu Chigusa1, Seiichi Tomotaki2

  • 1Department of Gynecology and Obstetrics, Kyoto University, Kyoto, Japan.

JMA Journal
|August 22, 2022
PubMed

Insights

Children with severe fetal growth restriction (sFGR) born preterm show lower neurodevelopmental scores, particularly in language and social skills. Early monitoring and intervention are crucial for these infants.

Area of Science:

  • Neonatal Development
  • Pediatric Neurology
  • Perinatal Medicine

Background:

  • Fetal growth restriction (FGR) impacts fetal development, leading to potential long-term health issues.
  • Severe FGR (sFGR) in preterm infants poses significant risks for neurodevelopmental outcomes.
  • Limited data exists on the long-term neurodevelopmental trajectory of sFGR infants in Japan.

Purpose of the Study:

  • To investigate the neurodevelopmental outcomes of preterm-born children with sFGR in Japan.
  • To identify clinical factors associated with neurodevelopmental impairments in this population.

Main Methods:

  • Retrospective review of clinical data from 26 preterm sFGR cases and 26 preterm appropriate for gestational age (AGA) controls.
  • Assessment of developmental quotient (DQ) using the Kyoto Scale of Psychological Development at 1 and 2 years corrected age.

Main Results:

  • Preterm sFGR infants exhibited significantly lower overall DQ scores compared to AGA controls (80 vs. 90.5).
  • The sFGR group showed significantly impaired scores specifically in the Language-Social domain (72.5 vs. 88).
  • Fetal body weight and its Z-score at birth correlated significantly with DQ scores, unlike duration of growth arrest or gestational age at birth.

Conclusions:

  • Preterm infants with sFGR demonstrate greater neurodevelopmental deficits, particularly in language and social skills.
  • Continuous long-term follow-up and targeted interventions are essential for preterm sFGR children.
  • Birth weight and its deviation from norms are key indicators for neurodevelopmental outcomes in sFGR.
Abstract

Keywords:
developmental quotientfetal growth restrictionneurodevelopmentpreterm birthsmall for gestational age

More Related Videos

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.5K
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

86.3K

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.7K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.6K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
171
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
42.3K
Intellectual Disability01:29

Intellectual Disability

Intellectual disability (ID) is a neurodevelopmental condition characterized by deficits in intellectual and adaptive functioning that manifest during the developmental period. This condition encompasses challenges in reasoning, memory, problem-solving, and learning, accompanied by impairments in everyday life skills, such as communication, self-care, and social interactions. Intellectual disability affects approximately 1% of the population in the United States, impacting an estimated 5...
144